Toxicity testing part 4

Mitochondria tests

Mitochondria are the energy producing furnaces of the body’s cells. Fats, carbohydrates and proteins can be metabolised to produce the body’s energy molecule called ATP. ATP (ADP+P) is shuttled across the mitochondrial membrane by translocator (TL) proteins in to the cytosol where is produces energy, ADP is then taken back in to the mitochondria to reform ATP. If the TL proteins are blocked by toxins it can affect energy production. It has been seen that up 40% of TL’s can be blocked in chronic fatigue. The mitochondrial translocator protein / mitochondrial membrane studies by Acumen can identify any toxins that are adducted to the mitochondrial DNA (different to genomic DNA found in the nucleus) or that are blocking translocator protein affecting energy production.

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Toxicity testing part 3

Testing for heavy metals

If you think you have metal toxicity you can look beyond a hair mineral analysis, which is commonly used. There are two tests that may be of use. First you can look at the red-cell form of the glutathione S-transferase enzyme (GST). GST is a family of enzymes that conjugates a toxin to reduced glutathione. Red blood cell GST is concerned with the detoxification of metals. Assessing this red blood cell enzyme can detect which metals you have been intoxicated with.
Another test to use is to quantify serum metallothionein and the metals it is carrying. Metallothionein is a cysteine-rich protein localised to the membrane of the Golgi apparatus of the cell. They have the capacity to bind metals and may provide protection against metal toxicity.

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