So, today I’m going to consider oestrogen metabolism a little closer. The detoxification of oestrogen through the liver is controlled by the genetic expression of various liver enzymes, the metabolites of which can have a huge impact on your health. To make it simple to remember oestrogen can be metabolised to E2 which is a safe / protective form of oestrogen; E4 and harmful type of oestrogen; or E16 an extremely toxic and carcinogenic form of oestrogen. In fact the ratio of E2 to E16 is an indicator of getting breast cancer. If you have more E16 than E2 the risk is high, if you have more E2 than E16 the risk is lower.